Here are the NCAA DI rushing touchdown leaders in 2021-22 campaign.
| 1 | Rasheen Ali | Fr. | RB | 23 |
| – | Tyler Allgeier | So. | RB | 23 |
| 3 | Tavion Thomas | So. | RB | 21 |
| 4 | Malik Cunningham | Jr. | QB | 20 |
| – | Breece Hall | Jr. | RB | 20 |
| – | Hassan Haskins | Sr. | RB | 20 |
| 7 | Jerome Ford | Jr. | RB | 19 |
| 8 | Deuce Vaughn | So. | RB | 18 |
| – | Kenneth Walker III | Jr. | RB | 18 |
| 10 | Travis Dye | Jr. | RB | 16 |
| – | Alton McCaskill | Fr. | RB | 16 |
| – | Lew Nichols | Fr. | RB | 16 |
| 13 | TreVeyon Henderson | Fr. | RB | 15 |
| – | Bryant Koback | Jr. | RB | 15 |
| – | Jaren Mangham | Jr. | RB | 15 |
| – | Sincere McCormick | Jr. | RB | 15 |
| – | Rachaad White | Sr. | RB | 15 |
| – | Charles Williams | Sr. | RB | 15 |
| 19 | Tyler Badie | Sr. | RB | 14 |
| – | Camerun Peoples | Jr. | RB | 14 |
| – | Brian Robinson Jr. | Sr. | RB | 14 |
| – | Garrett Shrader | Jr. | QB | 14 |
| – | Kyren Williams | Jr. | RB | 14 |
| 24 | B.J. Baylor | Jr. | RB | 13 |
| – | Kennedy Brooks | Sr. | RB | 13 |
| – | Leddie Brown | Sr. | RB | 13 |
| – | Ty Chandler | Sr. | RB | 13 |
| – | Zach Charbonnet | Jr. | RB | 13 |
| – | Snoop Conner | Jr. | RB | 13 |
| – | Samson Evans | So. | RB | 13 |
| – | Shermari Jones | Sr. | RB | 13 |
| – | Adrian Martinez | Jr. | QB | 13 |
| – | DeWayne McBride | So. | RB | 13 |
| – | Dameon Pierce | Sr. | RB | 13 |
| – | Clint Ratkovich | Sr. | RB | 13 |
| – | Brad Roberts | Jr. | RB | 13 |
| – | DeAndre Torrey | Sr. | RB | 13 |
| – | Malik Willis | Jr. | QB | 13 |
| 39 | Braelon Allen | Fr. | RB | 12 |
| – | Max Borghi | Sr. | RB | 12 |
| – | Jakobi Buchanan | Jr. | RB | 12 |
| – | Dustin Crum | Sr. | QB | 12 |
| – | Montrell Johnson | Fr. | RB | 12 |
| – | Abram Smith | Sr. | RB | 12 |
| – | Sean Tucker | So. | RB | 12 |
| 46 | Marquez Cooper | So. | RB | 11 |
| – | Matt Corral | Jr. | QB | 11 |
| – | Blake Corum | So. | RB | 11 |
| – | Haaziq Daniels | Jr. | QB | 11 |
| – | Sam Hartman | So. | QB | 11 |
