Here are the NCAA DI blocks leaders in 2021-22 campaign.
| 1 | Walker Kessler | So. | 7-1 | F | 155 |
| 2 | Jamarion Sharp | Jr. | 7-5 | C | 148 |
| 3 | Johni Broome | Fr. | 6-10 | F | 131 |
| 4 | Chet Holmgren | Fr. | 7-0 | C | 117 |
| 5 | Mark Williams | So. | 7-0 | C | 110 |
| 6 | Christian Koloko | Jr. | 7-1 | C | 102 |
| 7 | KC Ndefo | Sr. | 6-6 | F | 96 |
| – | Kevin Samuel | Sr. | 6-11 | C | 96 |
| 9 | Osun Osunniyi | Sr. | 6-10 | C | 94 |
| 10 | Ike Obiagu | Sr. | 7-2 | C | 93 |
| – | Drew Pember | Jr. | 6-10 | F | 93 |
| 12 | Ryan Kalkbrenner | So. | 7-1 | C | 89 |
| 13 | Obinna Anochili-Killen | So. | 6-8 | F | 87 |
| 14 | E.J. Liddell | Jr. | 6-6 | F | 83 |
| – | Clifton Moore | Sr. | 6-10 | F | 83 |
| 16 | Jalyn Hinton | Jr. | 6-6 | F | 81 |
| – | DaRon Holmes II | Fr. | 6-10 | F | 81 |
| – | Trayce Jackson-Davis | Jr. | 6-9 | F | 81 |
| – | Kur Kuath | Sr. | 6-10 | F | 81 |
| 20 | Jayveous McKinnis | Sr. | 6-7 | F | 79 |
| 21 | Marcus Bingham Jr. | Sr. | 6-11 | F | 77 |
| 22 | Stephen Clark | Jr. | 6-9 | F | 75 |
| – | Hall Elisias | Sr. | 6-7 | F | 75 |
| 24 | Kaodirichi Akobundu-Ehiogu | So. | 6-9 | F | 74 |
| – | Makhel Mitchell | So. | 6-10 | F | 74 |
| 26 | Brison Gresham | Sr. | 6-9 | F | 71 |
| – | Nathan Mensah | Sr. | 6-10 | F | 71 |
| – | Isaiah Whaley | Sr. | 6-9 | F | 71 |
| 29 | Yauhen Massalski | Sr. | 6-9 | F | 70 |
| 30 | Zach Austin | So. | 6-4 | F | 69 |
| – | Dajour Dickens | Sr. | 7-0 | F | 69 |
| 32 | Max Brooks | So. | 6-7 | F | 68 |
| – | Keegan Murray | So. | 6-8 | F | 68 |
| 34 | Jesse Edwards | So. | 6-11 | C | 67 |
| – | Mouhamadou Gueye | Sr. | 6-9 | F | 67 |
| – | Kadin Shedrick | So. | 6-11 | F | 67 |
| 37 | Efe Abogidi | So. | 6-10 | F | 66 |
| 38 | Armando Bacot | Jr. | 6-10 | F | 65 |
| – | Ryghe Lyons | Sr. | 6-10 | C | 65 |
| 40 | Terrell Brown | Sr. | 6-10 | C | 64 |
| 41 | Jaylan Gainey | Sr. | 6-9 | F | 63 |
| 42 | Colin Castleton | Sr. | 6-11 | F | 62 |
| – | Nelly Joseph | So. | 6-9 | F | 62 |
| 44 | Jalen Duren | Fr. | 6-11 | C | 61 |
| – | Austin Johnson | Jr. | 6-9 | F | 61 |
| 46 | Jubrile Belo | Sr. | 6-9 | F | 60 |
| 47 | Grant Basile | Jr. | 6-9 | F | 59 |
| – | Jake Stephens | Sr. | 6-8 | C | 59 |
| 49 | Teafale Lenard | Fr. | 6-7 | G | 58 |
| – | Jalen Slawson | Sr. | 6-7 | F | 58 |
