Here are the NCAA DI home run leaders in 2021-22 campaign.
| 1 | Ivan Melendez | Jr. | INF | 32 |
| 2 | Luke Franzoni | Sr. | INF | 29 |
| 3 | Matt Coutney | Sr. | 1B | 27 |
| – | Max Wagner | So. | INF | 27 |
| – | Tommy White | Fr. | INF | 27 |
| 6 | Jason Hinchman | Sr. | UT | 26 |
| – | Wyatt Langford | So. | UT | 26 |
| – | Kevin Parada | So. | C | 26 |
| 9 | Andy Garriola | Sr. | INF | 25 |
| – | Vance Honeycutt | Fr. | cf | 25 |
| 11 | Chris Alleyne | Sr. | INF | 24 |
| – | Tim Elko | Sr. | INF | 24 |
| – | Jud Fabian | Sr. | OF | 24 |
| – | Dakota Kotowski | Sr. | OF | 24 |
| – | Brendan Tinsman | Jr. | C | 24 |
| 16 | Tayler Aguilar | Jr. | OF | 23 |
| – | Brett Johnson | Jr. | INF | 23 |
| – | Dalton Rushing | So. | C | 23 |
| – | Brock Wilken | So. | INF | 23 |
| 20 | Dylan Crews | So. | OF | 22 |
| – | Sonny DiChiara | Sr. | INF | 22 |
| – | Carter Graham | So. | INF | 22 |
| – | Trey Lipscomb | Sr. | INF | 22 |
| – | Max Ryerson | So. | OF | 22 |
| – | Matthew Shaw | So. | INF | 22 |
| 26 | Michael Carico | So. | C | 21 |
| – | Ian Farrow | So. | OF | 21 |
| – | Logan Gallina | So. | C | 21 |
| – | Jake Gelof | So. | INF | 21 |
| – | Brock Jones | Jr. | OF | 21 |
| – | Christopher Sargent | Jr. | 1B | 21 |
| 32 | Tim Borden | So. | INF | 20 |
| – | Peyton Graham | So. | INF | 20 |
| – | Joe Kinker | Jr. | 1B | 20 |
| – | Tyler Locklear | So. | INF | 20 |
| – | Brendan O’Donnell | Jr. | OF | 20 |
| – | Alberto Osuna | So. | DH | 20 |
| – | Bryson Worrell | Sr. | OF | 20 |
| 39 | Drake Baldwin | Jr. | C | 19 |
| – | Jarrod Belbin | Jr. | UT | 19 |
| – | Ryan Cermak | Jr. | INF | 19 |
| – | Andrew Cossetti | Sr. | C | 19 |
| – | Zach Dezenzo | Sr. | INF | 19 |
| – | Jake Hyde | So. | INF | 19 |
| – | Tyler Johnson | Sr. | UT | 19 |
| – | Luc Lipcius | Sr. | 1B | 19 |
| – | Ubaldo Lopez | Sr. | INF | 19 |
| – | Carter Mathison | Fr. | OF | 19 |
| – | Nolan McLean | So. | UT | 19 |
| – | Griffin Merritt | Jr. | OF | 19 |
