Here are the Vanguard University Lions all-time strikeouts leaders.
| 1. | 245 – ISAAC, Sean – 2015-16 | |
| 2. | 195 – HARRIS, Marcus – 2001-04,16 | |
| 3. | 160 – HILL, Schuyler – 2018-19 | |
| 4. | 138 – GARCIA, Gabriel – 2011-12 | |
| 5. | 129 – GUERNSEY, Michael – 2004-06 | |
| 6. | 127 – WALKER, Anthony – 2000-01 | |
| 7. | 117 – KASHOU, Michael – 2017-20 | |
| 8. | 112 – JESSUP, Richard – 2006-09 | |
| 9. | 109 – TORREY, Scott – 2014-15 | |
| 10. | 108 – LUMANLAN, Chris – 2016-17 | |
| 11. | 103 – STEELE, Tyler – 2016-17,19 | |
| 12. | 100 – CARLS, Christopher – 2007-09 | |
| 13. | 98 – JONES, Dustin – 2007-08 | |
| 98 – DAUGHERTY, Ryan – 2018-19 | ||
| 15. | 88 – RIVERA, Eddie – 2014 | |
| 16. | 87 – VOECHTING, Clayton – 2013-14 | |
| 17. | 85 – BROWN, Clay – 2005-06 | |
| 18. | 83 – REID, Bryce – 2008-11 | |
| 83 – PURPURA, Robert – 2010-11 | ||
| 20. | 81 – ECHOLS, Britt – 2002 |