Here are the NCAA DI strikeouts leaders in 2021-22 campaign.
| 1 | Cooper Hjerpe | So. | P | 161 |
| 2 | Drew Thorpe | So. | UT | 149 |
| 3 | Austin Peterson | Sr. | P | 147 |
| 4 | Tanner Hall | So. | P | 146 |
| 5 | Parker Messick | So. | P | 144 |
| 6 | Shemar Page | Sr. | P | 143 |
| 7 | Justin Campbell | Jr. | P | 141 |
| 8 | Hurston Waldrep | So. | P | 140 |
| 9 | Gabriel Hughes | Jr. | UT | 138 |
| 10 | Jake Bennett | So. | P | 133 |
| 11 | Brycen Mautz | So. | P | 129 |
| 12 | Andrew Taylor | So. | P | 126 |
| 13 | Matt Duffy | So. | P | 124 |
| 14 | Zebby Matthews | Jr. | P | 122 |
| – | Jason Savacool | So. | P | 122 |
| 16 | Trey Dombroski | Jr. | P | 120 |
| – | Pete Hansen | So. | P | 120 |
| 18 | Carson Palmquist | So. | P | 118 |
| 19 | Preston Johnson | Jr. | P | 117 |
| 20 | Joe Simeone | Sr. | P | 116 |
| 21 | Brett Gillis | Jr. | UT | 115 |
| – | Dylan Tebrake | Jr. | P | 115 |
| 23 | Kyle Jones | Jr. | P | 114 |
| 24 | Connor Noland | Sr. | P | 113 |
| – | Nolan Santos | So. | P | 113 |
| 26 | Pat Pridgen | So. | P | 112 |
| – | Tyler Schweitzer | So. | P | 112 |
| 28 | Daniel Avitia | Fr. | P | 111 |
| – | John Michael Bertrand | Sr. | P | 111 |
| – | Thomas Harrington | So. | P | 111 |
| – | Cade Kuehler | So. | P | 111 |
| – | Quinn Mathews | Jr. | P | 111 |
| – | Juaron Watts-Brown | Fr. | P | 111 |
| 34 | Colin Fields | Jr. | P | 110 |
| – | Pat Gallagher | Jr. | P | 110 |
| 36 | Mason Adams | Jr. | P | 108 |
| – | Chase Dollander | So. | P | 108 |
| – | Garrett Saylor | Jr. | P | 108 |
| 39 | Cory Lewis | So. | P | 107 |
| – | Trystan Vrieling | Jr. | P | 107 |
| 41 | Brandon Birdsell | Jr. | P | 106 |
| – | Nolan DeVos | Jr. | P | 106 |
| 43 | Dylan DeLucia | Jr. | P | 105 |
| – | Rhett Lowder | So. | P | 105 |
| 45 | Spencer Giesting | So. | P | 104 |
| – | Josh Loeschorn | Sr. | P | 104 |
| – | Connor O’Halloran | So. | p | 104 |
| 48 | Chase Burns | Fr. | P | 103 |
| – | Jared Poland | Jr. | P | 103 |
| – | Zeke Wood | Jr. | P | 103 |
